Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, serves as a cell surface receptor, facilitating the axonal transport of beta-secretase and presenilin 1 via kinesin I. Crucial for neurite growth, neuronal adhesion, and axonogenesis, APP is a 100-140 kDa transmembrane glycoprotein with multiple isoforms due to alternative splicing. Cleavage by beta- and gamma-secretases produces beta amyloid, the primary constituent of senile plaques, a major feature of Alzheimer's disease. Aberrant regulation and processing of APP are linked to Down's syndrome, early onset familial Alzheimer's disease, and cerebral hemorrhage.