Insect cells facilitate high protein expression levels, with post-translational modifications akin to those in mammalian cells, easy scalability, and simplified cell growth suitable for high-density suspension cultures in large-scale production. Many post-translational modification pathways found in mammalian systems are also present in insect cells, enabling the creation of recombinant proteins that closely resemble native mammalian proteins in terms of antigenicity, immunogenicity, and functionality. Baculovirus expression systems serve as potent and adaptable delivery and expression tools for achieving high recombinant protein expression in insect cells, with reported expression levels up to 500 mg/L.