Gray-Out is a veterinarian designed topical cream for gray horses with melanoma. It uses natural ingredients such as frankincense, grapeseed oil, turmeric, green tea, and nicotinamide that have demonstrated anti-cancer activity in scientific studies. ​The cream is mild, with little to no adverse reactions in most cases. It is designed to limit growth of tumors and ideally cause regression. On average, it takes about 90 days to determine if your horse is responding to the cream. Directions for use: Apply a small amount to all affected areas daily. If the irritation occurs or if the horse becomes pruritic (itchy), the application can be every other day to every two days. It is common that the skin becomes lighter, loses pigment, with use. Please refer to the research tab for more information on the active ingredients.