Hyperforin: The Proved "Mood Enhancing" Active in St. John's Wort. New clinical research reveals hyperforin-rich Perika to be more effective in promoting positive mood than low hyperforin St. John's Wort. Perika's HyperiSure DifferenceHyperforin is rather unstable and can lose potency over time. However, using the patented HyperiSure System technology, Perika contains a guaranteed level of hyperforin to deliver clinically proven effectiveness. Perika is scientifically advanced to maintain a healthy emotional outlook.