Prior to using medication, use Voogle. It is proven to be effective in treating white spot (Ich), Cryptocaryon, Columnaris, fungal and bacterial skin infections and other external diseases that can infect fresh- and saltwater fish. It does this by greatly increasing the resistance of the immune system and supporting the natural healing process. It is safe to use with all fish, all invertebrates such as shrimps, crabs and snails, corals and other lower organisms and will not harm aquarium plants. It will not harm the beneficial nitrifying bacteria in the biofiltration media. Remove all carbon from filters during treatment but keep the filters running. For the treatment of sick fish, put the carbon back in NOT before 14 days after the first dosage. Water changes are not needed after using this product.