Supports Detox Mechanisms Joint Health* With Vitamin B-6 L-Methionine is classified as an essential amino acid, which means that it cannot be manufactured by the body. It must be obtained through the diet or by supplementation. L-Methionine supports the production of the cellular antioxidant, glutathione, thereby assists in natural detoxification processes. In the body, L-Methionine can also be converted into SAMe (S-Adenosyl Methionine), a compound that supports healthy joints.* NOW L-Methionine is the natural L-form of this amino acid. The synthetic DL-form is never used in any of our amino acid products. As a dietary supplement, take 2 capsules daily as needed, preferably on an empty stomach.