Topricin Topricin Pain Cream 8 Oz - Topricin Pain Relief Cream offers an evolution in pain management. With 11 natural biomedicines, guaranteed Topricin Pain Relief Cream targets the underlying inflammation that causes pain. Topricin doesn't mask pain, we actually provide real, quantifiable, pain relief. Application: Generously apply 3-4 times daily or more often if needed, 3 inches on and around the affected area. Massage in until absorbed, re-apply before bedtime and in the morning.