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JAK-Stat Pathway RPMI-8226 Luciferase Reporter Cells by Cellomics Technology in Kuwait

JAK-Stat Pathway RPMI-8226 Luciferase Reporter Cells by Cellomics Technology

KWD 0
– 1 +

Special Features

  • Produces IgG λ light chains, mimicking monoclonal gammopathy
  • Demonstrates high proteasome activity, a common target in MM therapy
  • Ideal for modeling bortezomib resistance and dexamethasone sensitivity
  • Lacks CD19 expression, but expresses plasma cell marker CD138
  • Often used with U266 and MM.1S for comparative drug testing

Description

Cell Lineomics Technology, LLC has engineered a stable cell line that mimics the RPMI-8226/JAK-Stat pathway, intended for hematologic malignancy research, focusing on plasma cell biology, drug resistance, and apoptosis. This cell line secretes IgG λ light chains, a common trait in monoclonal gammopathy. It displays high proteasome activity, making it valuable for modeling bortezomib resistance and dexamethasone sensitivity. It lacks CD19 expression but expresses the plasma cell marker CD138. This cell line is often used alongside U266 and MM.1S for comparative drug testing.

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