Selective Inhibition in Rat Hypothalamic Synaptosomes
IC50 Values: 0.9 and >100 µM
Reduces Immobility in Forced Swim Test in Mice
وصف
This product acts as an antidepressant, selectively blocking norepinephrine uptake more effectively than 5-HT uptake in rat hypothalamic synaptosomes (with IC50s of 0.9 and over 100 µM, respectively); it reduces immobility time in mice during the forced swim test at doses of 8 and 16 mg/kg.