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بيت / Cayman Chemical / لوازم علوم الحياة
بروكلوربيرازين ماليات 250 ملغ من شركة كايمان كيميكال in Kuwait

بروكلوربيرازين ماليات 250 ملغ من شركة كايمان كيميكال

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مميزات خاصة

  • Dopamine D2 Receptor Antagonist: Blocks rat recombinant D2 receptors (Ki = 4.7 nM)
  • D2 Receptor Binding: Affinity for D2 in rat striatal membranes (Ki = 2.9 nM)
  • D3 Receptor Interaction: Binds to rat recombinant D3 receptors (Ki = 35 nM)
  • 5-HT3 Receptor Binding: Affinity for 5-HT3 receptor in mouse neuroblastoma cell membranes (Ki = 1.2 μM)
  • Analgesic Effect: Increases paw licking latency in hot plate test at 2 mg/kg
  • Antiemetic Action: Inhibits apomorphine-induced emesis in dogs (ED50 = 0.34 mg/kg)

وصف

This product is a dopamine D2 receptor blocker, exhibiting strong affinity for rat recombinant D2 receptors (Ki = 4.7 nM) and rat striatal membranes (Ki = 2.9 nM). It also binds to rat recombinant D3 receptors (Ki = 35 nM) and the 5-HT3 receptor in mouse neuroblastoma cell membranes (Ki = 1.2 μM). In vivo, it increases paw licking latency in a hot plate test at 2 mg/kg, suggesting analgesic properties, and inhibits apomorphine-induced emesis in dogs (ED50 = 0.34 mg/kg).

منتجات شبيهه

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