*Source: E Coli or Yeast or Baculovirus or Mammalian Cell; *Purity: >90%; *Tag Information: His tagged; *Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.; *Seq: MHGPKATLQD IVLHLEPQNE IPVDLLCHEQ LSDSEEENDE IDGVNHQHLP ARRAEPQRHT MLCMCCKCEA RIKLVVESSA DDLRAFQQLF LNTLSFVCPW CASQQ; *Accession#: P06788.2; P06788; *Description: E7 protein has both transforming and trans-activating activities. Disrupts the function ofhost retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription .