Struggling with plaque in wider spaces between your teeth? Curaprox CPS 406 Perio interdental brush refills are expertly crafted for larger interdental areas and black holes – cleaning intensively without causing pain. The ultra-fine bristles ensure deep access while being gentle on gums. Instructions: Use daily before brushing. Insert gently at the gum line without force. Replace when bristles show wear or splay. At Curaprox, we believe oral care should be effective, safe and joyful. That's why our products are developed in Switzerland with a focus on prevention, softness and smart design.