Regioselective alkylation and/or acylation of the hydroxyl groups leads to lipophilic phases with varying enantioselectivity, which are well suited for GC enantiomer analyses
Important advantage: many compounds can be analyzed without derivatization
Max. temperature for isothermal operation 200 °C, max. temperature for short isotherms in a temperature program 220 °C
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A large number of separations have been achieved, however, it is not possible to make a general prediction, which phase could solve a given separation task. Even for compounds with small structural differences or within homologous series the can be quite different. The descriptions below list some of the typical separations possible with individual phases.