DIM 3 represents a three-dimensional approach to supporting healthy estrogen metabolism. Healthy metabolism of exogenous and endogenous estrogens can be pivotal for hormonal balance. DIM promotes metabolism of estrogen into the favorable and protective 2-hydroxyestrone (2-OHE) metabolite versus production of 4-hydroxyestrone (4-OHE) and 16-alpha-hydroxyestrone (16-alphaOHE) metabolites. DIM's influence on 2-OHE production creates a more desirable ratio of 2-OHE to 16-alpha-OHE. Assessment of 2:16-alpha-OHE ratio appears to be useful in evaluating breast health. DIM has been studied for its role in supporting prostate health as well, by reducing dihydrotestosterone binding to androgen receptors. DIM (3,3'-diindolylmethane) supplementation with DIM is preferred over I3C due to I3C's undesirable breakdown products, including the dioxin-like molecule indolo[3,2-b]carbazole (ICZ). DIM has been found to support hormone metabolism and immune activity, and stimulate antioxidant and detoxification systems. CURCUMIN and BioPerine provide complementary support for DIM's role in healthy cell function. DIM 3 also provides support for both antioxidant and detoxification systems which, in turn, support cellular function and integrity.