DBS microvolume sampling requires only 10 to 20 μl per sample
Fewer experimental animals are required because Toxicokinetic data are derived from Toxicology animals, thereby eliminating satellite colonies
More consistent data are obtained through more serial sampling from individual animals and less reliance on composite data
The 3-step DBS procedure is much more straightforward than the cumbersome centrifugation, isolation and cleanup of plasma
On-substrate cleanup has the potential to convey greater analyte stability, especially for enzyme-sensitive compounds
وصف
Room temperature stability saves on cost of dry ice shipments. Shipping without dry ice allows more remote sampling, particularly important for human clinical trial samples. The FTA DMPK-A and FTA DMPK-B cards lyse cells and denature proteins on contact. Samples can be shipped and stored at ambient temperature and long-term stability has been demonstrated for analytes and metabolites sensitive to plasma enzymes.