Origin: Grade III transitional cell carcinoma of the bladder
Harbors activating HRAS mutation, beneficial for Ras signaling research
Commonly used to model invasive bladder cancer and study tumor suppressors
Demonstrates robust, consistent growth under standard culture conditions
Sensitive to various chemotherapeutics, employed in high-throughput drug screening
وصف
Cell Lineomics Technology, LLC has engineered a stable cell line for investigating the T24/JAK-Stat Pathway. This cell line, derived from grade III transitional cell carcinoma of the bladder, harbors an activating mutation in HRAS, making it valuable for Ras signaling studies. It's often employed to model invasive bladder cancer and study tumor suppressors like p53. This cell line exhibits robust and consistent growth under standard culture conditions and responds to various chemotherapeutic agents, making it ideal for high-throughput drug screening.