وصف
KP372-1 is a selective Akt inhibitor, showing at least 10-fold preference for Akt over other kinases like CDK1, ERK1, GSK3β, LCK, MEK1, PKA, PKC, and S6K. In acute myelogenous leukemia cells, it inhibits Akt, PDK1, and FLT3, reducing colony formation with an IC50 below 200 nM.
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