Reduces Neuronal Apoptosis in Cortex and Hippocampus
Decreases Body Weight Loss
Reduces Colon Shortening
Decreases Ulcer Severity
Reduces iNOS, IL-6, and IL-1β in BV-2 Microglial Cells
Reduces LPS-Induced Neuronal Inflammation in Mice
Reduces TNBS-Induced Ulcerative Colitis in Mice
وصف
A flavonoid exhibiting diverse biological activities; it reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells at concentrations of 10-200 µM; inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml); suppresses LPS-induced NO production and reduces levels of iNOS, IL-6, and IL-1β in BV-2 microglial cells; inhibits passive cutaneous anaphylaxis in mice at a dose of 5 mg/kg; mitigates body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis; reduces cortical and hippocampal neuronal apoptosis and enhances time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.