Alternative Names: C-reactive protein, CRP, PTX1, MGC88244, pentraxin 1, PTX1MGC149895
Production Source: Recombinant Mouse C-Reactive Protein/CRP, expressed from HEK293 Cells with His tag at the C-terminal
Molecular Mass: Approximately 24.2 kDa
Purity Level: > 95% as determined by SDS-PAGE and HPLC
Endotoxin Level: < 1.0 EU per 1μg of the protein by the LAL method
Preparation Method: Lyophilized from 0.22μm filtered solution in PBS (pH 7.4)
Reconstitution Instructions: Centrifuge tubes before opening. Reconstitute to a concentration above 100 μg/mL. Dissolve lyophilized protein in distilled water
وصف
C-reactive protein (CRP), a pentraxin family member, binds to Strep. Pneumoniae's C-polysaccharide. It's a cyclic pentamer with five identical subunits, each having a lectin fold. The mouse CRP precursor is 225 amino acids long, with a 19 aa signal peptide and a 206 aa mature polypeptide. It's non-glycosylated and forms a pentamer via non-covalent bonds. IL-6 has little effect, while IL-1 is the primary inducer. CRP binds calcium-dependently to ligands like phosphocholine and injured cell membranes, acting as an opsonin and anti-inflammatory agent.
