REGENERATE Enamel ScienceTM Advanced Toothpaste is so effective that scientists had to develop a new water-free formula to prevent NR-5TM ingredients from reacting & unleashing their regenerative power in the tube. REGENERATE Enamel ScienceTM Advanced Toothpaste is powered by an exclusive and clinically proven NR-5TM technology. Thanks to its unique formulation, the Advanced Toothpaste has distinctive product characteristics: a dense formula with a rich texture due to the high content of ingredients. With each use of Advanced Toothpaste, its unique NR-5TM ingredients form a fresh supply of enamel mineral. These wrap and integrate onto the teeth and regenerate enamel** with exactly the same mineral tooth enamel is made of.