Pressure filtration holders maximize flow rates by applying positive pressure to the fluid over a broad membrane surface. Holders are autoclavable with one filter membrane that is sealed with removable wing nuts. All holders vent to release pressure.Holders have PTFE gaskets, silicone O-rings, and PTFE-coated photoetched stainless steel support screens to prevent nitrocellulose membranes from sticking. Sanitary holders are best used in-line to filter-sterilize liquids or gases. Sanitary inlet and outlet connections can be completely disassembled for thorough cleaning. Top plate has knobs for easy positioning over membrane.